"Turning back the hands of time"

Find out howGet involved
Introducing three remarkable progressions in the field

Yesterday

•  Successful transplantation of bone, soft tissue, and corneas occurred early in the 20th century.

•  Real progress in organ transplantation began in 1954 with the first successful kidney transplant.

•  During the 1960s, successful transplantation of pancreas/kidney, liver, isolated pancreas and heart occurred.

Today

•  108,000 Americans on the waiting list for donor organs.

•  Tissue-engineered products are used to induce bone and tissue growth, guide long bone regeneration and replace damaged cartilage.

•  Stem cells are available from a wide variety of sources. Animal and pilot human studies pave the way for clinical trials to treat many intractable diseases.

Tomorrow

•  A world where there is no donor organ shortage, where victims of spinal cord injuries can walk, and where weakened hearts are replaced. 

• Materials Science meets Regenerative Medicine with “smart” biomaterials that actively formulate tissue.

•  Novel techniques like removing organ cells and infusing new matter to the existing matrix to restore full functioning.
How we are asking the big questions in Gene Therapy
Click a stem cell to learn about our strategy and to meet the teams

Gene Therapy

The mission of our incubator is to accelerate gene therapy for human health and longevity.

We focus our work in three areas, click through to explore ongoing projects and meet the scientists.

Bone RejuvenationSkin Ageing TreatmentCancer Research

How we are asking the big questions

The mission of our incubator is to accelerate gene therapy for human health and longevity.

We focus our work in three areas, click through the tabs below to explore ongoing projects and meet the scientists.

Gene therapy is the umbrella term for our work in rejuvenative medicine.How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage, and stromal development from a population of highly pure, postnatal skeletal stem cells (mouse skeletal stem cells, mSSCs) to their downstream progenitors of bone, cartilage, and stromal tissue. We then investigated the transcriptome of the stem/progenitor cells for unique gene-expression patterns that would indicate potential regulators of mSSC lineage commitment.

Prof. Charles K. F. Chan
Founder
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Tom Ambrosi
Post-doc
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Matthew Murphy
Research Fellow
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Owen Marecic
Post-doc
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Lauren Koepke
CIRM Scholar
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Tom Andrews
Research Fellow
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Michael Lopez
LSRP
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Malachia Hoover
BS Cell and Molecular Biology, MS Biology
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Prof. Charles K. F. Chan
Founder
View profile
Tom Ambrosi
Post-doc
View profile
Matthew Murphy
Research Fellow
View profile
Owen Marecic
Post-doc
View profile
Lauren Koepke
CIRM Scholar
View profile
Tom Andrews
Research Fellow
View profile
Michael Lopez
LSRP
View profile
Malachia Hoover
BS Cell and Molecular Biology, MS Biology
View profile

Gene therapy is the umbrella term for our work in rejuvenative medicine.How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage, and stromal development from a population of highly pure, postnatal skeletal stem cells (mouse skeletal stem cells, mSSCs) to their downstream progenitors of bone, cartilage, and stromal tissue. We then investigated the transcriptome of the stem/progenitor cells for unique gene-expression patterns that would indicate potential regulators of mSSC lineage commitment.

Prof. Charles K. F. Chan
Founder
View profile
Tom Ambrosi
Post-doc
View profile
Matthew Murphy
Research Fellow
View profile
Owen Marecic
Post-doc
View profile
Lauren Koepke
CIRM Scholar
View profile
Tom Andrews
Research Fellow
View profile
Michael Lopez
LSRP
View profile
Malachia Hoover
BS Cell and Molecular Biology, MS Biology
View profile

Gene therapy is the umbrella term for our work in rejuvenative medicine.How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage, and stromal development from a population of highly pure, postnatal skeletal stem cells (mouse skeletal stem cells, mSSCs) to their downstream progenitors of bone, cartilage, and stromal tissue. We then investigated the transcriptome of the stem/progenitor cells for unique gene-expression patterns that would indicate potential regulators of mSSC lineage commitment.

Prof. Charles K. F. Chan
Founder
View profile
Rachel Brewer
CIRM scholar
View profile

Gene therapy is the umbrella term for our work in rejuvenative medicine.How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage, and stromal development from a population of highly pure, postnatal skeletal stem cells (mouse skeletal stem cells, mSSCs) to their downstream progenitors of bone, cartilage, and stromal tissue. We then investigated the transcriptome of the stem/progenitor cells for unique gene-expression patterns that would indicate potential regulators of mSSC lineage commitment.

Prof. Charles K. F. Chan
Founder
View profile
Isaac Bakerman
Post-doc
View profile
Rachel Brewer
CIRM Scholar
View profile
Mike Lopez
LSRP
View profile

 International recognition

Coverage in top scientific journals

The published works of our lab members describe an inspiring vision of Rejuvenative Medicine.

Updated regularly, here you will find a showcase of the team's major publications and previews of forthcoming projects.

Scroll down and click through the title links to view our top papers.

For a full catalogue of publications, please click here.

"Endochondral ossification is required for haematopoietic stem-cell niche formation."
Chan, C. K. et. al.
Nature

How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage, and stromal development from a population of highly pure, postnatal skeletal stem cells (mouse skeletal stem cells, mSSCs) to their downstream progenitors of bone, cartilage, and stromal tissue. We then investigated the transcriptome of the stem/progenitor cells for unique gene-expression patterns that would indicate potential regulators of mSSC lineage commitment. We demonstrate that mSSC niche factors can be potent inducers of osteogenesis, and several specific combinations of recombinant mSSC niche factors can activate mSSC genetic programs insitu, even in nonskeletal tissues, resulting in de novo formation of cartilage or bone and bone marrow stroma. Inducing mSSC formation with soluble factors and subsequently regulating the mSSC niche to specify its differentiation toward bone, cartilage, or stromal cells could represent a paradigm shift in the therapeutic regeneration of skeletal tissues.

Chan, C. K., Chen, C., Luppen, C. A., Kim, J., DeBoer, A. T., Wei, K., Helms, J. A., Kuo, C. J., Kraft, D. L., Weissman, I. L.

"Endochondral ossification is required for haematopoietic stem-cell niche formation."
Chan, C. K. et. al.
Cell

How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage, and stromal development from a population of highly pure, postnatal skeletal stem cells (mouse skeletal stem cells, mSSCs) to their downstream progenitors of bone, cartilage, and stromal tissue. We then investigated the transcriptome of the stem/progenitor cells for unique gene-expression patterns that would indicate potential regulators of mSSC lineage commitment. We demonstrate that mSSC niche factors can be potent inducers of osteogenesis, and several specific combinations of recombinant mSSC niche factors can activate mSSC genetic programs insitu, even in nonskeletal tissues, resulting in de novo formation of cartilage or bone and bone marrow stroma. Inducing mSSC formation with soluble factors and subsequently regulating the mSSC niche to specify its differentiation toward bone, cartilage, or stromal cells could represent a paradigm shift in the therapeutic regeneration of skeletal tissues.

Chan, C. K., Chen, C., Luppen, C. A., Kim, J., DeBoer, A. T., Wei, K., Helms, J. A., Kuo, C. J., Kraft, D. L., Weissman, I. L.

"Endochondral ossification is required for haematopoietic stem-cell niche formation."
Chan, C. K. et. al.
Science

How are skeletal tissues derived from skeletal stem cells? Here, we map bone, cartilage, and stromal development from a population of highly pure, postnatal skeletal stem cells (mouse skeletal stem cells, mSSCs) to their downstream progenitors of bone, cartilage, and stromal tissue. We then investigated the transcriptome of the stem/progenitor cells for unique gene-expression patterns that would indicate potential regulators of mSSC lineage commitment. We demonstrate that mSSC niche factors can be potent inducers of osteogenesis, and several specific combinations of recombinant mSSC niche factors can activate mSSC genetic programs insitu, even in nonskeletal tissues, resulting in de novo formation of cartilage or bone and bone marrow stroma. Inducing mSSC formation with soluble factors and subsequently regulating the mSSC niche to specify its differentiation toward bone, cartilage, or stromal cells could represent a paradigm shift in the therapeutic regeneration of skeletal tissues.

Chan, C. K., Chen, C., Luppen, C. A., Kim, J., DeBoer, A. T., Wei, K., Helms, J. A., Kuo, C. J., Kraft, D. L., Weissman, I. L.

 Lab tour video

Enjoy a stroll around the Stanford campus in sunny Palo Alto, California and into our lab at the Lorry I. Lokey stem cell research building.

We are blessed to enjoy one of the best learning, research and living environments in the world.

The Lab Store

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Be a Friend of The Lab and become a rejuvenation philanthropist today.

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Show your support by donating and receive an honour in return!

To discuss more extensive or ongoing support of our work, sponsorship and partner opportunities,
please reach out via the contact form below, or email rejuvenativemedicine@stanford.edu

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Accusamus numquam voluptatibus voluptatum eum distinctio non eum. Voluptatem qui delectus doloremque. Ut debitis officia necessitatibus et earum. Est libero autem ipsa ut neque ex esse. Nostrum maxime ut eos labore enim qui eos sed.

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Accusamus numquam voluptatibus voluptatum eum distinctio non eum. Voluptatem qui delectus doloremque. Ut debitis officia necessitatibus et earum. Est libero autem ipsa ut neque ex esse. Nostrum maxime ut eos labore enim qui eos sed.

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Accusamus numquam voluptatibus voluptatum eum distinctio non eum. Voluptatem qui delectus doloremque. Ut debitis officia necessitatibus et earum. Est libero autem ipsa ut neque ex esse. Nostrum maxime ut eos labore enim qui eos sed.

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Est quia quam temporibus dignissimos eos quo. Non iste soluta eveniet. Voluptatem ipsam ab a tempore doloribus aut. Maiores molestias eveniet dolorem incidunt sit itaque. Qui occaecati veritatis.

Accusamus numquam voluptatibus voluptatum eum distinctio non eum. Voluptatem qui delectus doloremque. Ut debitis officia necessitatibus et earum. Est libero autem ipsa ut neque ex esse. Nostrum maxime ut eos labore enim qui eos sed.

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Accusamus numquam voluptatibus voluptatum eum distinctio non eum. Voluptatem qui delectus doloremque. Ut debitis officia necessitatibus et earum. Est libero autem ipsa ut neque ex esse. Nostrum maxime ut eos labore enim qui eos sed.

Donate

Every donation keeps the hands of time turning backwards! We value your support however little or large, the best way to join up with the mission in this way is by giving through the Stanford Stem Cell Institute.

Please follow the simple steps to make a secure donation at this link.

Careers

We are always interested to hear from potential collaborators, and driven scientists keen to join our project.

Please reach out with relevant information by email to chazchan@stanford.edu

Contact

The Laboratory for Rejuvenitive Medicine
Email: chazchan@stanford.edu

Address:  Room G3, 3rd Floor, Lorry I. Lokey Stem Cell Research Building, 273 Campus Drive, Stanford, Palo Alto, California 9305, U.S.A.